In the KEGG pathways analysis, AGE-RAGE signaling pathway in diabetic complications (hsa04933), Small cell lung cancer (hsa05222), Proteoglycans in cancer (hsa05205), Focal adhesion (hsa04510), Measles (hsa05162), Protein processing in the endoplasmic reticulum (hsa04141), MAPK signaling pathway (hsa04010), Herpes simplex virus 1 infection (hsa05168), Regulation of actin cytoskeleton (hsa04810), and Adherens junction (hsa04520) were significantly enriched in the down-regulated group (Figure 2C). The gene discussed is RENBP; the disease is cancer.