Chemotherapy treatment has been shown to increase the expression of carcinoembryonic antigen (CEA) in colon and breast carcinoma cells (5-fluorouracil and docetaxel) and cancer-testis antigens in renal cell carcinoma and ovarian cancer cells (5′-aza-2′deoxycytidine) (14, 81–83). Here, CEACAM5 is linked to hereditary clear cell renal cell carcinoma.