In KIRC, high expression of ZC3H13 could significantly inhibit the infiltration of most tumor suppressor TIICs, including activated CD4 T cells, activated CD8 T cells, activated dendritic cells, CD56 bright natural killer cells, central memory CD4 T cells, type 1 T helper cells, and type 17 T helper cells. The gene discussed is CD4; the disease is neoplasm.