For example, the expression of ZC3H13 was significantly lower in tumor tissues than in adjacent normal tissues in KIRC, bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) etc. In contrast, the expression of ZC3H13 was significantly higher in the tumor tissues in cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), skin cutaneous melanoma (SKCM) etc. For KIRC, TCGA combined with GTEx also indicated that ZC3H13 was significantly lower in tumor tissues (Supplementary Figure 1B). This evidence concerns the gene ZC3H13 and carcinoma of esophagus.