The IPA analysis of these gene sets indicated the major altered canonical pathways in MPAL including IL-6 signaling, PPAR signaling, 14-3-3–mediated signaling, osteoarthritis pathway, D-myo-inositol-5-phosphate metabolism, antioxidant action of vitamin C, regulation of the epithelial mesenchymal transition by growth factors pathway, super pathway of inositol phosphate compounds, cardiac hypertrophy signaling (enhanced), and PI3K signaling in B lymphocytes (Supplementary Figure S4). Here, PPARA is linked to osteoarthritis.