Through drug target network analysis, it was found that several drugs, such as Alteplase, Heparin, ABX-IL8, NI-0801, and Rituximab, were associated with CXCL2, CXCL4, CXCL8, CXCL10, and CXCL13, which may be potential therapeutic targets and drugs for PAAD. This evidence concerns the gene CXCL8 and pancreatic adenocarcinoma.