Interestingly, we found multiple cell cycle regulators were up-regulated in PCa, including CCNB1, CCNB2, PLK1, TTK, AURKA, CDC20, BUB1, PTTG1, CDC45, CDC25C, CCNA2, and BUB1B [20–26]. This evidence concerns the gene BUB1 and posterior cortical atrophy.