CDH4 and neoplasm: Tanaka et al. (2016) revealed that SKAP2 is related to tumor-associated macrophage infiltration and facilitates the metastatic progression of lung cancer in mise. The prognostic value of SKAP2 was also reported in previous studies using bioinformatics analyses (Kuranami et al., 2015; Tanaka et al., 2016; Chen et al., 2019). Studies showed that CDH4 could be regulated by miR-211-5p to inhibit the proliferation, migration, and invasion of LUAD (Zhang et al., 2020). Besides, the aberrant expression of ligand–receptor pair LAMB1-ITGB1 was identified within tumor cells in LUAD (Chen et al., 2020).