Chronic hepatitis C promotes hepatic and systemic inflammation, with high production of CXCL8, CCL2, CXCL10, IFNγ, and IL12p70, among others (13), and activation and exhaustion of the immune system, with increased levels of PD1 and PDL1 (53). The gene discussed is CXCL10; the disease is chronic hepatitis C virus infection.