The analysis of the altered pathways related to these genes (Table 4B) showed the only significant KEGG pathway identified was “primary immunodeficiency pathway” (q-value <0.05), with three SDE genes upregulated (CD8A, CD8B, and TNFRSF13C) in HIV/HCV-f. This evidence concerns the gene TNFRSF13C and inborn error of immunity.