We analyzed the association between changes in plasma biomarkers and liver disease severity scores (LSM and HVPG) during the follow-up (Figure 2), but we only found a positive association (p-value <0.05) between plasma variations of PD1, IL10, CXCL10, CCL2, and CXCL8 and the change in LSM values (Figure 2A). This evidence concerns the gene CCL2 and liver disorder.