IL-5RA intracellular signaling provoked eosinophils proliferation and exaggerated activation through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex, which manifested as chronic eosinophilic leukemia (CEL) (45). The gene discussed is LYN; the disease is Chronic Eosinophilic Leukemia, Not Otherwise Specified.