IL-5RA intracellular signaling provoked eosinophils proliferation and exaggerated activation through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex, which manifested as chronic eosinophilic leukemia (CEL) (45). Here, FIP1L1 is linked to Chronic Eosinophilic Leukemia, Not Otherwise Specified.