In NAFLD mice, liraglutide could improve the hypoadiponectinemia-induced inflammatory stress by inhibiting the MKK4/JNK signaling pathway, inhibit liver adipogenesis by activating AMPK, and induce autophagy through the AMPK/mTOR pathway, hence improving the levels of liver lipids (23, 198). Here, MAP2K4 is linked to adiponectin deficiency.