A study on whether and how the activation of GLP-1R affects proliferation and apoptosis of human pancreatic cancer cells has demonstrated that GLP-1RAs might activate cAMP in a GLP-1R-dependent manner, subsequently inhibiting the AKT and ERK1/2 signaling pathways, hence inhibiting the growth of transplanted tumors in vivo, as well as inducing apoptosis and inhibiting the proliferation of a human pancreatic cancer cell line in vitro (225). This evidence concerns the gene GLP1R and familial pancreatic carcinoma.