INS and congenital isolated hyperinsulinism: Mutations in 12 key genes (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, UCP2, HNF4A, HNF1A, HK1, PGM1, PMM2), which are involved in regulation of β-cell insulin secretion, can lead to CHI (3–5).