In a cohort of patients treated with glucocorticoid with high urinary THF+aTHF/THE, HSD11B2 promoter methylation in peripheral leukocytes was associated with the development of hypertension, suggesting a possible role of a modulation of HSD11B2 gene expression in the pathogenesis of steroid-induced hypertension (39). This evidence concerns the gene HSD11B2 and Hypertension.