HSD11B2 and hypertensive disorder: The two homozygous mutant probands showed the highest HSD11B2 mRNA levels (median 169, range 118–220 copies/μl) that progressively decreased in 221 AG heterozygous with hypertension (108, range 92–124 copies/μl), 221 AG heterozygous normotensives (23.35, range 8–38.7 copies/μl), and wild-type 221 AA subjects (5.5, range 4.5–14 copies/μl).