HSD11B2 and Hypertension: In this context, our study was aimed to identify an accurate method to detect and quantify HSD11B2 mRNA from urinary exosomes in samples from family members affected by AME (17) and in EH patients to investigate a possible relationship between urinary exosomal HSD11B2 mRNA, steroid ratio, HSD11B2 662 C>G genotype (corresponding to a 221 Ala>Gly substitution in the amino acid sequence), and hypertension status.