Whole-brain activations related to NF training with cognitive reappraisal were investigated with a 2 × 2 × 2 × 4 full factorial model [Group (MDD, control) × Gender (Female, Male) × Condition (L-R, R-L) × Run (NF1, NF2, NF3, NF4)] which revealed a main effect of group showing involvement of a dorsal fronto-parietal network during NF training (Figure 3A; top; Table 3). This evidence concerns the gene NF2 and major depressive disorder.