NR2F2 and neoplasm: Interestingly, NR2F2 (nuclear receptor subfamily 2, group F, member 2) also known as COUP-TFII (COUP transcription factor 2) (Qin et al., 2010), a major angiogenesis regulator during development and within the tumor microenvironment, has been shown to drive angiopoietin-1 (Ang-1) expression in pericytes; moreover, conditional ablation of Nr2f2 in adult mice leads to compromised neo-angiogenesis in tumors and embryos (Suri et al., 1996; Pereira et al., 1999), supporting a role for pericytes in angiogenesis.