The high affinity of SARS-CoV-2 RBD for ACE2 in conjunction with the wide distribution of the ACE2 and colocalization with TMPRSS2, which allows S2 subunit release and fusion to host cells, may imply the broad clinical manifestations of COVID-19, ranging from subclinical symptoms to severe acute respiratory syndrome and multiple organ damages (Shulla et al., 2011; Hoffmann et al., 2020; Walls et al., 2020; Yang et al., 2020). The gene discussed is ACE2; the disease is COVID-19.