Numerous clinical studies revealed that decreased plasma adropin concentration is related to CVDs, such as hypertension (Gu et al., 2015; Gulen et al., 2016; Bolayır et al., 2018), cardiac syndrome X (Celik A. et al., 2013), CAD (Wu et al., 2014; Zhao et al., 2015, 2016; Ertem et al., 2017), and conditions linked to endothelial dysfunctions (Topuz et al., 2013; Oruc et al., 2017). Here, ENHO is linked to endothelial dysfunction.