Similarly, a downregulation in liver Enho mRNA expression was observed in mice with genetically induced obesity due to a deficiency of the leptin receptor (Lepob/Lepob) or the melanocortin receptor (lethal yellow Ay/a, Mc3r–/–, and Mc4r–/–) (Kumar et al., 2008). This evidence concerns the gene ENHO and obesity due to melanocortin 4 receptor deficiency.