Intraperitoneal (i.p.)injection of 26RFa during glucose tolerance tests in mice reduced glucose-induced hyperglycemia by the enhancement of insulin synthesis and targeted tissue insulin sensitization (co-expression of GPR103, glucose transporter type 4, and insulin receptor in the muscles, liver, and adipose tissues) (Prévost et al., 2015). This evidence concerns the gene QRFPR and Hyperglycemia.