Further studies showed that adropin therapy in combination with exercise was effective in alleviating NASH progression in C57BL/6J mice fed on a high-fat diet or an MCD diet, possibly due to an adropin anti-inflammatory effect via a reduction in ROS levels, which suppresses NLR family pyrin domain containing 3 (NLRP3) activation (Yang et al., 2021). Here, NLRP3 is linked to metabolic dysfunction-associated steatohepatitis.