Whereas, studies carried out on transgenic B6 mice overexpressing adropin (Adr-Tg) on a high cholesterol diet did not confirm an adropin protective function against hypercholesterolemia and arteriosclerosis, suggesting that adropin does not influence cholesterol uptake, nor circulation-synthesis clearance (Ghoshal et al., 2018). The gene discussed is ENHO; the disease is Hypercholesterolemia.