STAT3 and cancer: Additionally, 153 compounds such as Licoricidin, Limonin and Wogonin have been found to have anti-cancer effects by affecting the corresponding signaling pathways, mainly involving the Signal Transducer and Activator of Transcription 3 (STAT3) signaling pathway, PI3K/Akt/mTOR signaling, Wnt/β-catenin signaling pathway (Rasul et al., 2012; Ji et al., 2017; Chen et al., 2018).