Moreover, ursolic acid, isolated from Spreng (bearberry), Rhododendron hymenanthes Makino, Eriobotrya japonica, etc., plays an anti-cancer role in human ovarian cancer cells through apoptosis induction, cell cycle arrest and down-regulation of PI3K/AKT pathway, which is mediated by reactive oxygen species (Ros) and matrix metalloprotein (MMP). Here, AKT1 is linked to cancer.