INS and type 2 diabetes mellitus: However, we discerned that the effect of naringin on [Ca2+]d is not linked to its potential insulinotropic effect (Hameed, 2018) because, in isolated cardiomyocytes from T2D mice (devoid of any insulin action), we observed a dose-dependent reduction of [Ca2+]d when incubated with naringin (100–300 μM) (Supplementary Figure S2).