Considering the amount of IL-1β secreted in the distal colon of Winnie mice together with our earlier results that a small molecule inhibitor of the NLRP3 inflammasome ameliorates colitis in Winnie mice (Perera et al., 2018), it is possible that UTA77 also prevents NLRP3 inflammasome activation. The gene discussed is IL1B; the disease is colitis.