BDNF and Alzheimer disease: Among them, lifestyle changes, also known as environmental enrichment, is widely known to promote memory preservation and decrease Aβ plaque in animal models of AD (Jankowsky et al., 2005; Balthazar et al., 2018), while also increasing the production of BDNF (Baraldi et al., 2013; Dong et al., 2018; Kaptan et al., 2019), suggesting that improvements in cognitive performance and neurogenesis are related to a more active life (Garthe et al., 2016).