Although EMT may be induced by diverse factors including differential expression of microRNAs, TGF-β, Notch or Wnt signalling, as well as factors in the tumour microenvironment such as hypoxia, only TGF-β and hypoxia signalling have been explored to date for the role of UCHL1 in breast cancer. The gene discussed is TGFB1; the disease is breast carcinoma.