Using two DUB activity-based probes (discussed in more detail in the following section), TAMRA-ubiquitin-VME (TAMRA: tetramethylrhodamine, VME: vinyl methyl ester) and Biotin-ubiquitin-VME, the authors identified UCHL1 as the most active DUB across over a large cohort of breast cancer cell lines and aggressive breast cancer tumour tissue samples [54]. Here, UCHL1 is linked to breast cancer.