For example, Kessler and co-workers used an advanced chemical proteomics approach identify a set of oncogenic substrates of USP18 that appeared to be more susceptible to irradiation, suggesting that selective inhibition of USP18 could sensitise chronic myeloid leukaemia patients to radiotherapy [116]. The gene discussed is USP18; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.