Treatment with Nrf2 inhibitor ML385 abrogated the increased luciferase intensity of Foxo1 reporter plasmid induced by TAZ overexpression and impeded the TAZ stimulation of Foxo1, which was an important modulator of cellular antioxidant defense and its ablation in uteri caused infertility owing to the alteration of epithelial integrity along with aberrant decidual response29,41. This evidence concerns the gene WWTR1 and Infertility.