Within the first 36 h after Salmonella infection the Naip/NLRC4 inflammasome is required for Caspase-1 mediated cell extrusion associated with IL-18 production whereas at a later time point (>72 h post infection) non-canonical inflammasome activation involving Caspase-11 is needed7,40. Here, NAIP is linked to Salmonella Infections.