Activity of transaminases and gamma glutamyl transferase (γ-GT) in plasma but also markers of glucose and lipid metabolism as well as levels of C-reactive protein (CRP), plasminogen activator inhibitor 1 (PAI-1), uric acid, leptin and body mass index (BMI) as well as waist circumference were significantly higher in NAFLD patients than in controls. This evidence concerns the gene SERPINE1 and metabolic dysfunction-associated steatotic liver disease.