It has been reported that MIR4435-1HG (also termed LINC00978) promotes the progression of hepatocellular carcinoma by inhibiting p21 and E-cadherin expression via EZH2-mediated epigenetic silencing30 and promotes cell proliferation and tumorigenesis via regulating microRNA-497/NTRK3 axis in gastric cancer31, there is no report regarding PDAC. This evidence concerns the gene EZH2 and hepatocellular carcinoma.