GSK3B and Behcet disease: Altogether, beside the well-documented anti-inflammatory effect exerted by Li on the innate GSK-3β pathways and consequently on circulating pro- and anti-inflammatory cytokines, our observations indicate that response to Li in BD patients may be underpinned by adaptive HLA-mediated inflammatory processes, fitting with the known anti-inflammatory effect driven by Li that may contribute to its therapeutic efficiency31.