PLK1 and cancer: Specifically, we found one set of cell cycle and cell proliferation regulating genes, including the proliferation-specific transcription factor Foxm1 (a typical proliferation factor that plays an important role in organ morphogenesis and development of cancer), and its target genes, such as Ccnb1, Ccnd1, Ki67, Cenpa, Cenpe, Cenpf, Aurka, Plk1, and Ccna2, were significantly decreased in PRMT7−/− lungs (Fig. 5A).