In addition, in the metastasis group, compared with the group with low plasma exo-miR-3157-3p expression, the positive rate of MMP2 and VEGF in tumor tissues in the group with high plasma exo-miR-3157-3p expression were relatively higher, while the positive rate of KLF2, TIMP2 and Occludin were lower (Fig. S2C, D). The gene discussed is VEGFA; the disease is neoplasm.