Interestingly, TNF-α signalling via the NF-κB pathway was significantly downregulated (Supplementary Fig. S6B) with a reduction ranging from 7- to 40-fold in expression of some of its prooncogenic target genes (e.g., JUNB, FOS, DUSP1) and melanoma-related genes (e.g., EGR3, NR4A3, CCN1; Supplementary Fig. S6D). This evidence concerns the gene CCN1 and melanoma.