Of note, our results in leukemia-derived HAP1 cells, acute monocytic leukemia–derived THP1 cells, and the human ccRCC ex vivo model overlap with those found in patient-derived melanoma specimens (Supplementary Fig. S6E), indicating that the effect on NF-κB signaling may be a universal feature of NUC-7738 treatment. This evidence concerns the gene NFKB1 and nonpapillary renal cell carcinoma.