Currently, multiple treatment options are available to patients with rheumatoid arthritis (RA), including conventional synthetic disease-modifying antirheumatic drugs (csDMARDs; methotrexate, leflunomide, sulfasalazine, and hydroxychloroquine), tumor necrosis factor inhibitor (TNFi) biologics (adalimumab, etanercept, infliximab, certolizumab pegol, and golimumab), and non-TNFi biologics (biologics targeting a different mechanism of action; abatacept, rituximab, anakinra, and tocilizumab) [1–3]. Here, TNF is linked to rheumatoid arthritis.