For example, sEV miR-23a-3p promotes PD-L1 expression in macrophages, thereby inhibiting T cell response in hepatocellular carcinoma, while cervical cancer cells escape T cell immunity by sEV miRNA-1468-5p-induced overexpression of PD-L1 on lymphatic vessels [91, 92]. This evidence concerns the gene CD274 and hepatocellular carcinoma.