We found in IDH-wt cohort that the cluster with high proportion of endothelial cells and B-cells prominently showed a greater number of samples with CDKN2A/B deletion and similarly in IDH-mut astrocytomas we found that in cluster 2 significant number of samples presented CDKN2A/B deletion. The gene discussed is IDH1; the disease is astrocytoma (excluding glioblastoma).