Recent studies have reported that many lncRNAs are involved in the immunoregulation of DLBCL, including SMAD5-AS1, which suppresses DLBCL progression via the Wnt/β-catenin pathway [58]; HOTAIR, which predicts a worse prognosis of DLBCL patients [59]; and SNHG14. The gene discussed is HOTAIR; the disease is diffuse large B-cell lymphoma.