In addition, LINC00473 deletion via transfection with siRNA inhibited PC progression and activated the killing capacity of CD8 + T cells by promoting miR-195-5p-targeted downregulation of PD-L1 and by increasing Bax, IFN-γ and IL-4 expression and decreasing Bcl-2, MMP-2, MMP-9 and IL-10 expression [85]. The gene discussed is CD274; the disease is pachyonychia congenita.