Notably, KCNQ1OT1 directly binds to and decreases miR-15a and leads to recovery of PD-L1 expression, consequently inhibiting cytotoxicity and proliferation and promoting apoptosis of CD8 + T cells while promoting viability, migration, invasion, EMT and suppressing apoptosis of PCa cells [91]. The gene discussed is CD274; the disease is posterior cortical atrophy.