CD8A and bladder transitional cell carcinoma: Intriguingly, higher TEXscores were accompanied with rising M0 and M2 macrophage infiltration in TCGA-LUSC, TCGA-LUAD, TCGA-STAD, and TCGA-BLCA, albeit with bare statistical significance; in contrast, CD8 + T cells level negatively correlated with TEXscore, implying that TEX contributed to remodeling of the immunosuppressive microenvironment (Additional file 5: Figure S5A–D).