In addition, Brownmiller et al. found a significant difference in the expression of the Y chromosome lncRNA linc-SPRY3-2/3/4 between radiation-sensitive and radiation-resistant non-small cell lung cancer cells, and confirmed that knockdown of linc-SPRY3-2/3/4 promoted cell viability and resistance to apoptosis after treatment with 8 Gy [28]. The gene discussed is SPRY3; the disease is non-small cell lung carcinoma.