After adjusting age, sex, myocardial infarction, congestive heart failure, cerebrovascular disease, peripheral vascular disease, dementia, diabetes, hypertension, COPD, CRP, GFR, K+, HCO3-, phosphate, BMI, MAP, WBC, Hb, BUN, Cr, mechanical ventilation, CCI, APACHE II score, SOFA score, CRRT causes, and AKI causes, it was found that with the increasing albumin, the risks of 28-day and 90-day mortality of patients decreased (p < 0.001) (Figs. 3 and 4). The gene discussed is ALB; the disease is chronic obstructive pulmonary disease.