HCC cell lines also provide evidence of variable PRRX1 level, with a notable low expression in HLF (a high migrating cell line), although not reflecting PRRX1 correlation to CTNNB1 (there is an extensive heterogeneity in the mutational landscape of the cell lines – making it hard to attribute even their phenotypic differences to the various mutations [26]). Here, PRRX1 is linked to hepatocellular carcinoma.