When ranked based on Pearson score, the topmost PRRX1-co-expressed genes included several known candidates in HCC, e.g. TGFB3, HNF1A, IL10 [3] as well as novel targets such as PLXDC1, EMX2OS, and GLT8D2 (Fig. 2a). This evidence concerns the gene EMX2OS and hepatocellular carcinoma.