The results of KEGG pathway enrichment analysis showed that those 1966 common DEGs in three populations were enriched in the following pathways: protein processing in endoplasmic reticulum (57 genes), NF-κB signaling pathway (25 genes), antigen processing and presentation (16 genes), osteoclast differentiation (22 genes), Toll and Imd signaling pathway (27 genes), fluid shear stress and atherosclerosis (32 genes), necroptosis (30 genes), and apoptosis (19 genes) (Fig. 3C). Here, TLR4 is linked to atherosclerosis.