CREB1 and bacterial infectious disease with sepsis: As IL-1β–induced downregulation of VE-cadherin expression mediates lung vascular injury in bacterial sepsis via suppression of the transcription factor CREB,17 we addressed the possibility that SARS-CoV-2 infection may also lead to lung hyperpermeability of the endothelium via disruption of the lung endothelial barrier due to downregulation of VE-cadherin expression.