NTHL1 and Parkinson disease: To generate a BER-defective PD model, we crossed the nth-1(ok724) loss of function allele (Fensgård et al., 2010; Kassahun et al., 2018) into the BY273 (pdat-1GFP; pdat-1WTα-syn) background (Nass and Blakely, 2003).