Inspired by the use of the human cold‐sensitive channel TRPM8 to program successful treatment of experimental muscle atrophy in response to cooling sensation,[28] we tested the mammalian heat‐sensitive channels TRPV1 and TRPV4 for temperature‐responsive activation of synthetic calcium‐dependent signaling cascades (Figure S1a, Supporting Information). Here, TRPV1 is linked to muscle atrophy.