Generally, group 1 ILCs are associated with antitumor properties, including direct cytotoxicity13 and high expression of antitumor cytokines including IFN‐γ, perforin, and granzyme B.7, 13, 26, 32, 33Compared with normal adjacent tissue, a higher frequency of activated tumor protective hILC1s, marked by expression of high levels of CD69 and CD44,34 were described in gastrointestinal tumors. This evidence concerns the gene IFNG and digestive system neoplasm.