In contrast to other reports, in which the number of pathologists involved in PD‐L1 evaluation in HNSCC was small, and the pathologists often did not have specific expertise in the field, this study involved 10 pathologists from 10 different centres who, after taking a training course on the evaluation of the CPS in HNSCC, showed almost perfect agreement, which was best for the most relevant CPS cut‐off of ≥1, and with kappa values always in the range of almost perfect.17, 18, 25. This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.