A ChAd63 prime/modified vaccinia virus Ankara (MVA) boost vaccine expressing the PfME-TRAP antigen (malaria multiple epitopes, ME, fused to the Pf thrombospondin-related adhesion protein, TRAP) elicited monofunctional CD8+ IFN-γ T cell responses that correlated with sterile protection in 3/14 (21%) subjects [17]. This evidence concerns the gene CD8A and malaria.