ALDH7A1 and Seizure: Seizures and neurodevelopmental delays are likely multifactorial in PDE-ALDH7A1: 1) Accumulation of α-AASA and P6C due to the block at α-aminoadipic semialdehyde dehydrogenase is presumed to be neurotoxic; 2) Pyridoxal-5’-phosphate is the active pyridoxine metabolite, which is used as a cofactor for about 70 biochemical reactions in the human body [14].