CD4 and cranioectodermal dysplasia: Among HLA‐class II‐associated disorders, CeD offers a unique possibility to study disease‐driving, pathogenic CD4+ T cells, given the knowledge of the disease‐driving antigen and the availability of HLA‐DQ:gluten tetramer tools.[26, 27] In this study, we have characterized HLA‐DQ:gluten tetramer+ cells with RNA‐seq and mass cytometry and demonstrate how the phenotype of the cells shifts as a function of gluten exposure.