OXT and obesity due to melanocortin 4 receptor deficiency: Accordingly, whether oxytocin might be developed as a therapeutic treatment for obesity is controversial, and not a topic for this short commentary; for a recent review, see McCormack et al.3Although there is evidence that pharmacologically, oxytocin can reduce food intake, the question of whether oxytocin and/or oxytocin (Oxt) neurones have a significant role in the normal, physiological regulation of appetite has long provoked an extreme polarisation of views, which we examine here.