However, compared to consumption of a high‐fat diet, supplementation of tea polyphenols significantly reduced weight gain, reduced expression of inducible enzymes (inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2)) which are upregulated with inflammation, reduced mRNA expression of pro‐inflammatory cytokines (TNF‐α, IL‐1β and IL‐6) associated with liver inflammation, and lowered liver fat content (Rahman et al., 2020). Here, NOS2 is linked to Hepatitis.