EPHA2 and cataract: Thus, to confirm this finding, in an independent experiment, we determined progression of cataract in cohorts of Epha2+/+, Epha2+/−, and Epha2−/− mice (n ≥ 18 per group) on C57BL/6J background from 11 to 45 weeks of age or until severe cataract developed (grade 4 to 5).