In comparison, Epha2+/− mice presented with mild ACC up to 18 weeks, moderate ACC by 27 weeks (grade >2, P < 0.001) and severe ACC by 38 or 45 weeks of age (grade 4 or 5, P < 0.001; Figs. 2A, 3, Supplementary Table S2). The gene discussed is EPHA2; the disease is adrenal cortex carcinoma.