EPHA2 and cataract: On C57BL/6J background, Epha2+/− mice developed moderate cataract at 27 weeks (P < 0.01) and severe cataract by 38 and 45 weeks of age (P < 0.001; Fig. 12B); however, the mice on mixed background developed only moderately severe cataracts by 64 weeks of age.