EPHA2 and Age-related cataract: However, homozygous Epha2-knockout mice carrying an insertion mutation in the Epha2 gene and predicted to produce truncated protein (Jackson Laboratory strain #006028) generated by homologous recombination,66 on C57BL/6J background, develop mild nuclear cataract and exhibit smaller lenses with impaired refractive quality and suture formation; reports regarding development of age-related cataract in these mice are conflicting.38