EPHA2 and adrenal cortex carcinoma: Epha2+/+ and Epha2+/− 11, 18, and 27-week-old mice exhibited similar mild anterior cortical lens opacity (Fig. 1, Supplementary Table S1) whereas 38, 45, and 52-week-old Epha2+/− mice exhibited significantly severe anterior cortical opacities (grade 4 or 5) than age-matched Epha2+/+ mice (38 weeks, P < 0.001; 45 and 52 weeks, P < 0.01; see Fig. 1, Supplementary Table S1), indicating development of ACC.