EPHA2 and adrenal cortex carcinoma: In Epha2−/− mice, moderately severe ACC was observed earlier, at 11 weeks of age (grade >2, P < 0.05), and severe ACC by 18 or 27 weeks of age (grade 4 or 5, P < 0.001), compared to Epha2+/+ mice (see Figs. 2A, 3, Supplementary Table 2).