Epha2−/− mice, compared to Epha2+/+ mice, displayed mild ACC by 18 weeks that progressed to moderately severe ACC by 27 weeks (grade >2, P < 0.01) and severe ACC by 38 weeks of age (grade 4 or 5, P < 0.001; see Figs. 10A, 11, Supplementary Table S3). This evidence concerns the gene EPHA2 and adrenal cortex carcinoma.