PLK1 and cancer: Additionally, abnormal expression of KIF14 is often accompanied by abnormal expression of BUB1, TTK, PLK1, CREBBP, and CDK1 and affects the prognosis of several types of cancer (e.g., esophageal squamous cell carcinoma, glioblastoma, retinoblastoma, multiple myeloma, and acute myeloid leukemia) (37-, 39).